After the sticker is put on, any new effects that change the creature's base power and toughness will apply as normal, and when those effects expire, the creature will revert to the base power and toughness set by the sticker
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It already mills half of the opponent's library just by casting it, not needing to resolve, has a Ward that makes it hard to eliminate, and has stat line boosts and Annihilator based on the exiled cards in the game
This will be absolutely amazing in Lizard decks, but the +1/+1 ability is relevant for any deck that can get creatures in for combat damage
This means it can activate as many times as you want once you have your combo assembled