Nightmare Moon / Princess Luna provide an interesting multiplayer functionality by making friends while also referencing Nightmare Moon's affinity for the night and cards with Moons on them (Blood Moon, anypony?), and Twilight's abilities are obvious as the Princess of Friendship even if there aren't any Applejack, Fluttershy, Pinkie Pie, or Rainbow Dash cards to go with her yet (this means Wizards needs to get on the ball!)
With some healing cards, like Potion [Scarlet and Violet], you might just be able to score a massive OHKO
Landfall Commanders like Bristy Bill, Spine Sower, Tatyova, Benthic Druid, Azusa, Lost but Seeking, and The Gitrog Monster want Icetill Explorer, as do graveyard Commanders like The Necrobloom and Muldrotha, the Gravetide
I could never know how accurate I will be ewe
Ulamog, the Infinite Gyre I remember for a long time Ulamog, the Infinite Gyre was the gold standard of top-end plays in Commander