Conservative strategies include progressive resistance training to rebuild core stability, regular stretching and mobility work, adequate hydration (often challenging on GLP-1 therapy), and micronutrient supplementation including vitamin D3, calcium, and B12
However, this ignores the complex hormonal set-point that the body fights to maintain
Clinical trial data shows retatrutide has somewhat higher rates of GI side effects (nausea, diarrhea, vomiting) compared to tirzepatide, likely due to the additional glucagon receptor activation
However, if pain is severe, worsening, or accompanied by leg numbness, contact your PlexusDx provider immediately
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