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43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia
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[3] [4] The most significant factor is rapid weight loss , which is a common effect of GLP-1 and dual GIP/GLP-1 receptor agonists
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