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HNF1B-MODY can lead to a range of kidney abnormalities, including bilaterally hyperechogenic kidneys visible on prenatal ultrasound, multiple renal cysts, dysplastic multicystic kidneys, single kidneys, horseshoe kidneys, tubular dysfunction, nephropathy caused by hyperuricemia resulting in gout, renal magnesium depletion, and chromophobe renal carcinomas
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We will also discuss our recent efforts in developing drug-containing nanoparticles with specialized surface modifications that can enhance delivery to inflamed and fibrotic tissues particularly in the lungs and liver, for improved therapeutic outcomes
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