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A: Symptoms can include fatigue, pins and needles, low mood, and hair changes such as diffuse shedding or premature greying

Irisin inhibits Smad3 phosphorylation-mediated ferroptosis and fibrosis, leading to significant alleviation of renal tubular cell injury and fibrotic lesions in UUO, as revealed by results [168]

Activation of AMPK using 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) enhances mitochondrial biogenesis, promotes mitochondrial FAO, and reduces renal damage in AKI models (Jin et al., 2020