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In individuals with knee osteoarthritis, the natural levels of hyaluronic acid may be reduced, leading to increased friction, inflammation, and pain

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in [PMID: 19386527] Laboratory literature summary: Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects

Lind M, et al

Blots were incubated with HRP-conjugated secondary antibodies (BS13278, Bioworld Technology Inc., MN, USA) for 1 h, and protein expression was detected with ECL (WBULS0500, Millipore, MA, USA) by digital imaging systems (SYNGENE, Cambridge, UK)

Interleukin inhibitors : Ustekinumab (Stelara) targets IL-12 and IL-23 pathways, while risankizumab (Skyrizi) specifically inhibits IL-23