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Those with lighter skin types may see results in 1-3 months

Following heat stress, the expression of HSP70, HSP90, and sHSPs is upregulated, which promotes the refolding of misfolded proteins, facilitates the clearance of irreversible protein aggregates, and helps maintain organelle function, thereby supporting the survival of heat-sensitive germ cells and recovery of spermatogenesis (Maroto et al., 2025)

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But it is also a protocol where the monitoring is not optional

Given the increased potential for nausea and vomiting, it is important that the pre-sedation instructions allow for a period of withholding these drugs prior to sedation based on their half-life