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Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium
In nucleated cells, their functions are not limited to apoptosis, and caspases have been demonstrated to be involved in the regulation of multiple RCDs and related mechanisms, including pyroptosis (caspase-1), necroptosis (caspase-8), mitotic catastrophe (caspase-2), and regulation of inflammation [4]
10.1016/j.bbrc.2016.08.124 Biochem
Here, we reported that a short-term high fat-enriched diet worsens APAP-induced liver damage, by promoting liver accumulation of lipids that induces the activation of peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1)
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