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There is a standard text included in NICE guidelines which on the one hand allows departure from them on good grounds, but on the other hand expects both doctors and patients to be supported in choosing to follow them: Your responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available

If prescribed, your treatment plan may include injection instructions, dose guidance, supplies, follow-up support, and pharmacy coordination

The third level is causal proof, such as loss of effect after pathway inhibition or restoration of effect after pathway rescue

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