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Estrogens are secreted cyclically, inducing a negative feedback on gonadotropins and modulating the hypothalamic-pituitary-gonadal axis (Pentikinen et al., 2000)

PMID: 2155033 DOI: 10.1016/S0006-3495(90)82574-1 Crumb WJ Jr, Clarkson CW (1992): Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes

It works by signaling your pituitary gland to release more growth hormone (GH)

When free radical production exceeds your bodys ability to neutralize them, oxidative stress occurs, accelerating collagen breakdown and triggering excess pigmentation

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