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Miguens-Gomez 2021): A fast, neural-based release within 10-15 minutes of eating A slower, nutrient-based release ~60 minutes after eating, especially when nutrients reach the lower GI tract, Eating too quickly may short-circuit the gut-brain connection

The chemical composition interacts with local tissue, and if the pH deviates significantly from physiological norms, it triggers pain receptors and inflammatory mediators

Mast cells, a type of granulocyte, contain chemicals needed in the bodys immune response