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Their main actions include: Slowing gastric emptying This means food leaves the stomach more slowly, promoting a longer feeling of fullness after meals and reducing the post-meal rise in blood glucose

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Opportunity exists for therapies with better tolerability profiles, though it may be difficult for an agent to achieve both enhanced efficacy and tolerability

Ohara M, Ogawa K, Suda G, et al

miR-148a and miR-128-1 repress LDLR expression and inhibition of these miRNAs results in enhanced LDLR expression and clearance of circulating LDL