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doi:10.1056/NEJMoa2032183 Youmshajekian L, Tedeschi V
Available from: Accessed 10 Nov 2025
These and other studies gave impetus to the clinical development of the inhibitors of DPP-4 for diabetes therapy, and in a pivotal proof-of concept study by Ahren and coworkers in 2004, vildagliptin, developed by researchers at Novartis, showed hemoglobin A1c improvements to target levels of 7% in a 1-year trial, whereas a significant rise was observed in the placebo group (103)
Supraphysiological concentrations of GIP can also activate GIP receptors on L cells, potentially enhancing GLP-1 secretion
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