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By inhibiting this interaction, FOXO4-DRI allows reactivation of the apoptotic pathway in non-proliferative senescent cells, leading to their selective elimination without damaging healthy tissue
The correct sequence of the gene of interest (GOI) was confirmed by the Sanger sequencing service of Microsynth
It suppresses pro-inflammatory cytokines IL-6 and TNF-alpha while increasing superoxide dismutase (SOD) and glutathione (Pickart et al., 2015)
doi:10.1016/S0003-2697(03)00143-X
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