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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

A clinical study has shown that female E4 carriers who experienced late life weight loss were at an increased risk of developing dementia but not males (Kristoffer et al., 2015)

A bioorthogonal chemical reporter for the detection and identification of protein lactylation

Many patients in the United States report experiencing a dry mouth, uncharacteristic fatigue, mild headaches, or an intensified sensation of thirst within the first few weeks of escalating their dose