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While effective for immediate symptom resolution, this approach shuts down endogenous production by triggering a negative feedback loop
In the following section, we will highlight the strategy wherein nanoparticles are combined with scaffolds to improve the osteogenic effect and provide support for the defect
Natural IGF-1 is composed of 70 amino acids, while IGF-1 LR3 extends 13 amino acids through the N-terminus (MFPAMPLSLFLVN), increasing the total number of amino acids to 83
Simpson RW, Nicholson GC, Proietto J, Sarah A, Sanders KM, Phillips G, et al
Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
