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The changes in copper oxidation state may be advantageous, as dozens of enzymes may adopt it in catalyzing critical biochemical reactions such as detoxification, blood clotting, cellular respiration, antioxidant defense, and connective tissue regeneration
doi: 10.2337/db08-0625 116 GschwandtnerMDerlerRMidwoodKS
Hertz, L
Kwak, H
The key is timing and in what order you apply the treatments
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