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The circadian mismatch of artificial light at night (and lack of sunlight exposure during the day) may be reducing melatonin levels and increasing the risk of these chronic conditions

(1) Synthesis of Boc protected amino acids: Dissolve the required amino acids in dichloromethane, add potassium carbonate powder, stir evenly, add ethoxylated silica gel, continue stirring, and then add pyridine and N-methylmorpholine to obtain Boc protected amino acids

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This strategy is often used for proteins, peptides, and other large biomolecules that might be sensitive to degradation [60]