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Understanding why these changes occur, what to expect, and when symptoms require medical attention helps patients manage treatment effectively whilst maintaining therapeutic benefits

When a patients blood pressure is lower, their blood sugars improve, they can take a medication out of their daily regimen [sit] comfortably on an airplane without a seat belt extender, or [be] able to play with a young child without huffing and puffing, those are the changes that really improve quality of life. 3

A mixed model for repeated measurements was used to input any missing data from test subjects that discontinued treatment or required a dose of rescue medication

Statistical Analyses Analyses were performed using SAS version 9.4 or higher (SAS Institute, Inc., Cary, NC, US)

The dose can then be increased by 2.5 mg every 4 weeks or more, as tolerated, to a maximum of 15 mg weekly