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Reference: Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018)

Thermoregulation: Plays a role in body temperature regulation and the stress response, with effects noted on the hypothalamic-pituitary-adrenal axis 3

Some people may experience mild constipation for a few days

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Conclusions/interpretation A dose-dependent superiority on glycaemic efficacy and body weight reduction was evident with tirzepatide vs placebo, GLP-1 RAs and basal insulin