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Food and Drug Administration) If youre considering glutathione for skin-lightening or wellness, oral or topical alternatives appear safer, although their effects are more modest
Genetic Variations (GSTM1, GSTP1 Polymorphisms) Polymorphisms in genes encoding glutathione S-transferases (GSTs) can reduce detoxification capacity and glutathione efficiency by 20-40%
CLINICAL RELEVANCE Evidence that glutathione is involved in the metabolic disturbances which underlie diabetes, obesity, insulin resistance, and the metabolic syndrome continues to grow as well
Finally, dosage is an issue
Another meta-analysis of randomized controlled trials found that endothelial function in normal-weight and overweight but not obese patients with type 2 diabetes was significantly improved by supplementation with vitamin E and/or vitamin C (90)
