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The expression of NtMEK2 DD induced the generation of hydrogen peroxide and up-regulated the expression of defense-related genes including PR- genes, peroxidases and GSTs including GSTTU4 and GSTTU12 (Jeong et al., 2008)

People with low glutathione levels or those with less efficient detoxification genes are at a higher risk of developing the associated diseases

in 2002, the US Congress mandated that the CDC develop diagnostic guidelines for FAS and in 2004 a definition of a term that already had been used by some in the 1990s, fetal alcohol spectrum disorder (FASD), was adopted, [40] to include FAS as well as other conditions resulting from prenatal alcohol exposure

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