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Messier SP, et al
We can gain confidence from the successful approval of KRAS inhibitors, and there are reasons to believe that drugs targeting p53 will eventually be successful in the clinic
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95% CI [0.860.97])
Moreover, it was reported that supplementing the diet with the antioxidants N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014)
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