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In addition to the lean and ob/ob mice, the study included 3-KO mice and WT controls obtained from genetically verified breeding colonies

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There have been quite a few large studies on HRT, with some results showing increases in breast cancer, dementia, and heart disease, while other results show possible benefits for reducing heart disease or dementia.[ref][ref] The pendulum seems to be swinging back to HRT being recommended more often for menopause symptoms.[ref] This is a complex topic, and genetic variants as well as lifestyle factors likely matter

Many cases of prostate cancer tend to develop and spread slowly, which may offer a larger window for intervention

doi: 10.1128/mbio.00412-22 215 MoxonR.BaylissC.HoodD