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Importantly, these changes in mitochondrial mass are not related to engagement of apoptosis: inhibition of caspase activity using zVAD-fmk did not prevent increases in mitochondrial abundance per cell (Extended Data Fig
Options may include SGLT2 inhibitors, metformin, thiazolidinediones, or insulin for diabetes, noting that DPP-4 inhibitors also carry pancreatitis warnings
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