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The key signaling pathways associated with oxidative stress in asthma include the Nrf2, NFB, mitochondrial, MAPK, thioredoxin-1, and aldose reductase pathways

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Kornblau SM, Banker DE, Lemker E, Estrov Z, Faderl S, Verstovsek S, Cortes J, Garcia-Manero G, Koller CA, Ravandi-KBlood:ani F, Andreeff M , Jackson CE, Chen W, Petersdorf S, Estey E, Appelbaum FR

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Spermidines known autophagy-supporting properties [9] add to this by helping recycle and restore these pigment-producing cells

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