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Important Context: AOD-9604 completed six randomized, double-blind, placebo-controlled trials involving over 900 participants
Its pentadecapeptide structure and stability profile help provide consistent readouts across varied in-vitro systems
Finally, further studies should clarify the molecular pathways involved and extend the one-time application (much like the engraftment of neural stem cells [16] or bone marrow stromal cells [17] into the lesion site) to the continuous application for the recovery of pre-existing spinal cord injury
Parallels are drawn with more traditional neurodegenerative disorders, where a progressive proteopathy with prion-like propagation of toxic misfolded species is now known to play a key role
1 BPC-157 Medial Collateral Ligament Healing Cerovecki et al., Journal of Orthopaedic Research (2010) This follow-up study extended the BPC-157 healing model to surgically transected rat medial collateral ligaments (MCL), evaluating recovery at multiple time points across 90 days post-surgery
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