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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels
Contempre B, Dumont JE, Ngo B, Thilly CH, Diplock AT, Vanderpas J
Some people may require regular injections to maintain adequate levels for their entire lives, whilst others may just need an initial boost which can then be maintained through diet
These would provide steady drug levels without weekly injection burden
& Green, W.N
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