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INTRODUCTION The incretin hormones secreted by L cells in the ileum and colon are GLP-1 receptor agonists (RAs) [3]
4 Oral semaglutide, the first oral GLP-1 RA, launched as Rybelsus in 2019 for the treatment of type 2 diabetes mellitus (T2DM), achieved a revenue of USD 3,281.9 million in 2024
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Research has identified effects on blood vessel formation, growth factor expression, nitric oxide production, and cellular signaling cascades
The results across this body of literature are consistently positive: Tendon and ligament healing: Accelerated structural repair in Achilles tendon rupture and ACL tear models, with improved tensile strength and histological organization
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