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This effect proves particularly pronounced for visceral fat , the metabolically dangerous fat surrounding abdominal organs
2,539 adults with obesity or overweight with comorbidity, without T2D
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Therefore, GLP-1RA drugs like liraglutide or semaglutide can counteract DPP-4 degradation, prolonging the GLP-1R signal and maintaining insulin secretion via the mTOR-dependent HIF-1 pathway (34)
For the diabetes indication, there is no BMI minimum
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