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Running 8-week cycles with 4-week breaks means approximately 8 months of active use per year rather than 12
Neurochem Int 45: 619-626
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It comes from United States Pharmacopeia General Chapter 797, which sets a default beyond-use date for opened multi-dose vials of any kind
That said, there are foods that increase the activity of GST enzymes (those enzymes that help glutathione attach to toxins during detoxification)
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