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The details of its anti-fibrotic effects on multiple tissues and organs through activation of different signaling pathways and modulation of multiple targets are shown in Table 1
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In the aspect of HDAC2, there is also consistency showing that repeated electroconvulsive seizures treatment causes the up-regulation of HDAC2 expression both at the mRNA and protein levels in the rat frontal cortex, which further reduces the histone acetylation of H3 and H4 proteins and diminishes NMDA receptor-related genes involved in the development of epilepsy [103]
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We recently described the cell-penetrating peptide FOXO4-DRI as a senolytic drug 5
