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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
While B12 can be found in foods like meat, fish, and dairy, some people struggle to absorb enough through diet alone
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It is a synthetic form of B12 that contains a cyanide moleculethough the amount is negligible and considered safe for use in food supplements by European food safety authorities
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