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Retatrutide is an investigational triple agonist peptide (GIP, GLP-1, and glucagon receptor) currently under clinical development for the management of obesity and type 2 diabetes
Top Benefits : Reduces bloating and balances gut bacteria
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While adenosine triphosphate (ATP) signaling was enhanced in cultured DRG neurons treated with exendin-4, capsaicin sensitivity and calcium influx remained unaffected, suggesting GLP-1R predominantly modulating gut motility rather than pain signaling [55]
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