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The 8 mg dose is a clinically acceptable maintenance target if the 12 mg dose produces persistent grade 2 or higher nausea, vomiting, or diarrhea after two failed escalation attempts [1, 8]

Regul Pept 124(suppl):135148 Deacon CF, Holst JJ (2006) Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes