Though the trial was powered to only detect non-inferiority, the observed (non-significant) hazard ratio for semaglutide vs
Additionally, apart from IR being a new effective target for systemic PD treatment, studies on T2DM have found that ROS production and mitochondrial damage in muscle tissues of hyperglycemic mice can be normalized with antioxidant treatment and blood glucose control (56), suggesting that T2DM treatment strategies could provide new insights and strategies for future PD research and treatment
As a result, current understanding is based primarily on experimental and early-stage research rather than large-scale clinical evidence
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It is theorized that patients who are taking a GLP-1 agonist are at a greater risk for pancreatitis due to the medication causing an increase in stimulation of GLP-1 receptors located in the pancreas