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A meaningful proportion of these women can still hemolyze when exposed to strong oxidants like primaquine or tafenoquine [5]
However, these studies do not indicate effective and potential clinical therapeutic approaches for metabolic diseases
In a PI-IBS model, berberine treatment resulted in the downregulation of Proteobacteria and pathogenic Escherichia/Shigella strains, while promoting beneficial genera such as Lactobacillus , Clostridium IV , and Ruminococcus
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In contrast, its intestinal microbial metabolite, urolithin, possesses better biological activity and higher bioavailability [173]
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