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Glade MJ, Smith K
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However, it also represents a form of pathological compensation that further exacerbates cellular dysfunction and injury ( 3 Glucose metabolism in the normal heart The adult heart is a highly energy-dependent organ, and the maintenance of continuous, rhythmic contractile activity requires a stable and efficient supply of ATP ( Although glucose is not the primary energy substrate in the normal heart, its metabolism plays an essential role in maintaining cellular homeostasis and supporting rapid responses to metabolic stress ( Once transported into cardiomyocytes, glucose is first phosphorylated by hexokinase to generate glucose-6-phosphate, which subsequently enters multiple metabolic pathways ( In addition to glycolysis, a fraction of glucose-6-phosphate is diverted into the pentose phosphate pathway (PPP)
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