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Importantly for the translational impact of potential EEC-targeted therapies, comparisons between murine and human EECs via RNA-seq have established that receptors expressed in murine models are largely equivalent to those seen in humans 89
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GLP1 prevented increases in the atrial effective refractory period, P-wave duration, atrial conduction time, atrial conduction velocities and action potential duration, which were observed in dB/dB mice
Oral GLP-1s, such as oral semaglutide or tirzepatide are not as effective
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