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Safety, tolerability, and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers
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Although the drug was administered topically, systemic suppression of VEGF occurred, suggesting potential off-target effects beyond the ocular compartment (Sultana and Scondotto 2020)
Water enables hydrolytic degradation, and peptides in aqueous solution are much less stable than in their lyophilized form
Hebb DO (1949)
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