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No hepatic safety signal has been identified, a finding of particular importance given the hepatotoxicity that led to the discontinuation of competing oral GLP-1 programs
Crystallization of Pt GSTF8 in presence of ()-catechin and GSH Purified Pt GSTF8 in 30 mM Tris, pH 8, 200 mM NaCl, 1 mM EDTA was concentrated to 12.4 mg ml 1 using an Amicon Ultra-4 device (10 kDa cut-off) (Merck Millipore) and supplemented with 1 mM GSH and 25 mM ()-catechin immediately before crystallization
Clean reads were mapped to the corresponding reference genome using HISAT2 software 50
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