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Within the ARC of the hypothalamus CART-peptide containing neurons are surrounded by NPY expressing nerve terminals

Prioritize cold or room-temperature foods, as strong odors from hot meals may trigger nausea

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Although it was proposed that PYY 3-36 might exert its anorexigenic effects by activating Y2 receptors on POMC neurons in the ARC, the PYY 3-36 -induced inhibition of food intake has been shown to still occur in POMC knockout mice

It works "pretty well in most people" for improving blood sugar, she said, but "for weight, there does seem to be a little bit more variation" in how well it helps people trim down