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In contrast, the Grooved Pegboard Test, a commonly used measure of fine motor coordination and dexterity, demonstrates a broader dynamic range and has been shown to decline progressively with disease worsening, making it a more reliable response biomarker in longitudinal studies [512]

Copper is only required in trace amounts by the body, and too much copper buildup could theoretically cause nausea, abdominal pain, tiredness, liver damage, and neurological effects

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