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Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone
To date, the membrane receptor for K28 has not been definitively identified, although current evidence suggests that it may be the cellular HDEL receptor Erd2p
Werma Santos 10/27/2020 Write a review
Preclinical studies have demonstrated that TMAO can induce apoptosis in various target cells, such as human aortic vascular smooth muscle cells, 158 pancreatic acinous cells, renal tubular epithelial cells, 159 human aortic endothelial cells, 160,161 and neurons, 119 contributing to the development and progression of cardiovascular, renal, neurological, and pancreatic diseases
10.1007/s00239-004-2666-z 136 TorresM
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