These medications work by mimicking GLP-1s multiple mechanisms: they slow gastric emptying (keeping you full longer), suppress glucagon release from the pancreas (reducing glucose production), stimulate insulin secretion when blood sugar is elevated, and most importantly for weight loss, directly activate satiety centers in the brains hypothalamus
This suggests that, while bothersome, diarrhea is generally not severe enough to outweigh the benefits of the medication for most people
Neither drug should be used in people that have a medical history of the following: Heart disease Treatment with an MAOI currently or within the past 14 days Hyperthyroidism Agitation Substance use disorder Glaucoma Currently pregnant or breastfeeding Allergies to the medication Pulmonary hypertension (high blood pressure in the lungs) and valvular heart disease have been reported in people taking phendimetrazine or phentermine
In addition to the primary results noted above, he identified several other noteworthy observations from the study: The researchers note that while the mechanisms behind semaglutides cardioprotection are uncertain, the consistent effects across various cardiometabolic risk factors suggest that multiple interconnected pathways may be involved
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