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A key limitation: metformin's benefit in the DPP was attenuated in participants aged 60 and older, where the number needed to treat rose substantially

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It also works in synergy with higher molecular weight versions , and the combination of 0.1% 1.45MDa-HA + 0.1% 380 kDa-HA + 0.1% miniHA hydrated the skin significantly better than 0.3% 1.45MDa-HA alone