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It binds the growth hormone receptor (GHR), a class I cytokine receptor present as a preformed homodimer on target cells throughout the body
J Endocrinol, 1996
The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary
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Written by Emily Rodriguez, RDN, CSSD Registered Dietitian
