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Several studies have tested GLP-1 and combination medications for people with MASLD who have not yet progressed to MASH and have little or no fibrosis Another dual GLP-1/glucagon agonist, pemvidutide, reduced liver fat content by up to 69% in people with MASLD and no significant fibrosis, compared with 4% in the placebo group, and more than half achieved normal liver fat levels
In June 2021, the FDA approved its use for chronic weight management in adults who are overweight or obese A 2022 study finding once patients go off the medication the average weight gain rebound is about 2/3 of the total weight lost
doi: 10.1053/j.gastro.2004.07.024 89 AtarashiKTanoueTShimaTImaokaAKuwaharaTMomoseYet al
3.3 Safety Overall, 290 treatment-emergent adverse events were reported by 93 (59.6%) subjects (Table 3)
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