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Biomolecules 10 , 1211 (2020)
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ
FDA's own scientists recommended against it, citing inadequate physicochemical characterization, immunogenicity risk from aggregation and peptide-related impurities, and insufficient evidence of effectiveness
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Both 1/ values were similar to the corresponding apparent catalytic efficiencies and decreased for K105X mutants by up to one or two orders of magnitude (Fig
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